Stress Urinary Incontinence (SUI) is defined as "the complaint of involuntary loss of urine on effort  or physical exertion (e.g., sporting activities), or on sneezing or coughing" (1), and it is the most common type of urinary incontinence
Comparative effectiveness of Kelly plication plus local injection of autologous platelet-rich plasma (PRP) versus Kelly plication in women with stress urinary incontinence: a randomized clinical trial.

In this randomized clinical trial study, 60 consecutive women suffering from SUI were assigned to two groups by random block randomization: thirty patients were treated with Kelly plication, and 30 patients received PRP injection at the anterior vaginal wall where mid-urethra locates and Kelly plication. we used Urogenital Distress Inventory (UDI-6) questionnaire and International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) to evaluate and compare the effectiveness of the two treatment procedures in pre-treatment, 1, 3, and 6months post-treatment.

Among the 60 patients enrolled, the median age was 48.5 (range 27-72) years old. The median age in   patients   with  Kelly  plication   and   Kelly   plication   plus   PRP  treatments  were   49.3(11.5)   and 47(11.4), respectively. There was no statistical difference between the two treatment groups by age (p-value=0.772)
this study UDI-6 and ICIQ-SF scores showed incontinence improvement within both treatment groups during 1, 3, and 6months post-treatment. However, there was a statically significant difference between the two treatments by the UDI-6 questionnaire (p-value=0.012) but not by the ICIQ-SF questionnaire (p-value=0.112). The scores of both questionnaires revealed that Kelly plication and PRP procedure were more effective than Kelly plication alone.

Local injection of platelet-rich plasma seems safe, with a somewhat satisfactory response in treating female SUI at 1, 3, and 6months post-treatment. Yet how long the treatment effect could sustain remains unknown and awaits further studies.

Therefore, we highly recommend other studies with larger samples to confirm the PRP therapy efficacy in SUI patients.

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Behnia-Willison F, Nguyen TT, Norbury AJ, Mohamadi B, Salvatore S, Lam A. Promising impact of platelet rich plasma and carbon dioxide laser for stress urinary incontinence. European journal of obstetrics & gynecology and reproductive biology: X. 2020;5:100099
Long CY, Lin KL, Shen CR, Ker CR, Liu YY, Loo ZX, Hsiao HH, Lee YC. A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence. Sci Rep. 2021;11(1):1584.