Stress urinary incontinence (SUI) describes any involuntary loss of urine in response to increased intraabdominal pressure, such as during physical exertion, sneezing, or coughing. Platelet‐rich plasma (PRP) has rapidly gaining popularity in the treatment of many diseases. It had been demonstrated that platelets may help in treatment of SUI. 

To assess the efficacy and feasibility of transvaginal ultrasound guided PRP injections in the
treatment of SUI in females

prospective clinical study was conducted at the Department of urology, Beni-Suef university including 54 women with SUI. All patients were subjected to full history taking, complete physical examination and some routine investigations. All patients had answered an Arabic validated questionnaires (ICIQ-UI-SF and ICIQ-LUTSqol) to assess the severity of stress incontinence before and after treatment, showing the grade of the disease and the degree of improvement after treatment. Stress test and VLPP test were done before and after treatment.

Age of study participants ranged from 33 to 70 years with mean ± SD of 52.648 ± 8.519. Obstetric history of study participants ranged from 2 to 5 with mean ± SD of 3.333 ± 0.9316 and 42.6% of them was para 3. Overweight and obesity prevalence were 44.4% and 27.8% respectively. The prevalence of normal vaginal delivery was 74.1% among study participants. Leakage per day before injection ranged from 1 to 75 gm with mean ± SD of 30.037 ± 20.847. According to ICIQ SF score, eight (14.8%) patients had mild SUI, 25 (46.3%) patients had moderate SUI while 21 (38.9%) had severe SUI before injection

The efficacy of first injection in treatment of mild SUI was 50%. From those having moderate SUI, 5 patients improved and 20 patients still unchanged. The efficacy of first injection in treatment of moderate SUI was 20%. From those having severe SUI, 3 patients improved and 18 patients still unchanged. The efficacy of first injection in treatment of severe SUI was 14.3%. The overall efficacy of first injection in treatment of SUI was 22.2% After 2 doses of PRP injection 10 (18.5%) patients cured, 12 (22.2%) patients improved in severity and the failure rate was 59.3%. The efficacy of one dose of PRP injection in improving
of SUI was 22.2%; 50% in mild SUI, decreased to 20% in moderate SUI and decreased to reach 14.3% in severe SUI. While the efficacy of the second dose of PRP injection was 40%; 100% in mild SUI, decreased to 36% in moderate SUI and decreased to reach 31.3% in severe SUI.

PRP injections could be a safe and effective treatment option
for mild to moderate SUI in women. However, the synergistic effects of PRP as a combined
intervention with other treatment options should be tested. Further multicentric studies with large
sample size are recommended.