REGENERATIVE TECHNOLOGIES IN THE PREVENTION OF AUGMENTATION URETHROPLASTY RELAPSE

Pavlov V1, Kazikhinurov R1, Kazikhinurov A1, Khasanov A1, Shamsov B1, Le T1

Research Type

Clinical

Abstract Category

Urethra Male / Female

Abstract 653
Open Discussion ePosters
Scientific Open Discussion Session 108
Saturday 20th September 2025
13:00 - 13:05 (ePoster Station 1)
Exhibition
Male Prevention Stem Cells / Tissue Engineering Surgery
1. Bashkir State Medical University
Presenter
Links

Abstract

Hypothesis / aims of study
In recent years, the implementation of cell technologies shows effectiveness and encouraging results in various branches of medicine.  One of the promising methods is the use of multipotent mesenchymal stem cells from the stromal-vascular fraction (SVF) of autologous adipose tissue. This cell population includes many different types of cells such as stem cells, endothelial cells and smooth muscle cells of  blood vessel cells and their precursors, pericytes, fibroblast, macrophages, T-lymphocytes and etc. The mechanism of action is due to the presence of pericytes and endotheliocytes in SVF that promote neoangiogenesis. 
Aims of study. Perform a comparative analysis of the clinical efficacy of augmentation urethroplasty using oral mucosa according to standard procedures with and without injection of SVF obtained from autologous fat tissue.
Study design, materials and methods
From January 2019 to December 2023 115 augmentation urethroplasty with the use of oral mucosa were carried out, which 49 patients were treated with injections of stromal vascular fraction (SVF) obtained from autologous fat tissue.  Patients are examined according to clinical recommendations.  Age, etiology, localization, comorbidity and extent of stricture in both groups were comparable.  The average age of patients was 50±17 years.  The mean length of stricture was 5.5±2.5 cm. SVF was injected under the tissue of the recipient area (more often under the tunica albuginea of corpus cavernosum), the anastomosis area and under fixed oral graft.  The diagnostic criteria for relapses were: Qmax < 12 ml/sec, X-ray reduction of urethra narrowing ≤16 Ch, necessity of dilation or second surgical intervention.
Results
The frequency of relapses over 12 months in the group of patients, who had operated with the usage of SVF, was 6.1% (3 patients) and 15.1% (10 patients) with standard procedures at comparable observation times.
Interpretation of results
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Concluding message
The use of stroma-vascular fraction (SVF) obtained from autologous adipose tissue allows to improve short-term and long-term results of augmentation urethroplasty techniques. Furthermore, application of SVF could be a attractive option for prevention  of post-surgical complications.
Disclosures
Funding - Clinical Trial No Subjects Human Ethics Committee lLocal Ethics Committee of Bashkir State Medical University Helsinki Yes Informed Consent Yes
16/07/2025 15:17:02